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Related Concept Videos

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Description
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Related Experiment Video

Updated: Jan 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Quantification differences between supine and prone CT in interstitial lung disease.

Hyungin Park1, Ji-Yeon Han2, Jinwook Baek2

  • 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Clinical Imaging
|December 19, 2025
PubMed
Summary

Prone computed tomography (CT) shows high reproducibility for interstitial lung disease (ILD) assessment, comparable to supine CT. Caution is advised for longitudinal studies in advanced or ground-glass opacity-dominant ILD.

Keywords:
Interstitial lung diseaseProne positionQuantitative computed tomographyReproducibility

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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Area of Science:

  • Radiology and Imaging
  • Pulmonary Medicine
  • Medical Diagnostics

Background:

  • Interstitial lung disease (ILD) assessment often relies on computed tomography (CT).
  • Quantitative CT (QCT) offers objective measurements of lung abnormalities.
  • Evaluating measurement variability between supine and prone imaging is crucial for QCT reproducibility.

Purpose of the Study:

  • To compare measurement variability and reproducibility of prone QCT versus supine QCT in patients with ILD.
  • To assess the correlation of QCT measurements with pulmonary function test (PFT) parameters in different positions.
  • To identify factors influencing inter-positional variability in QCT measurements.

Main Methods:

  • Retrospective analysis of paired supine and prone CT scans from 277 ILD patients (Jan 2021-Dec 2023).
  • Lung abnormalities quantified using deep learning software; variability assessed by Bland-Altman and intraclass correlation coefficients (ICC).
  • Correlations with PFTs evaluated using Pearson's correlation and Steiger's Z-test; regression analyses identified variability predictors.

Main Results:

  • High reproducibility between supine and prone QCT (ICC > 0.75) with low variability (approx. 2% for fibrosis, 4% for total ILD extent).
  • Ground-glass opacity (GGO) exhibited the highest variability, especially in extensive disease.
  • Prone honeycombing showed stronger PFT correlation; hypersensitivity pneumonitis associated with greater total ILD variability.

Conclusions:

  • Prone QCT demonstrates high reproducibility and comparable PFT correlations to supine QCT.
  • Prone CT is reliable for single-time-point ILD assessments.
  • Longitudinal comparisons require caution in advanced or GGO-dominant ILD due to potential variability.