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Updated: Jan 8, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
Transcriptional restart: A new role for PARylation in overcoming DNA damage
Jingwei Liu1, Xiaoyu Song1, Liu Cao2
1The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning Province 110122, China.
Abstract:
PARP1 detects DNA damage and catalyzes PARylation of proteins to promote DNA damage response. In a study recently published by Nature Chemical Biology, Zhu et al.1 identify a new function for PARP1 in transcriptional restart by PARylation and stabilization of AFF1, which expands PARP1's role to transcriptional recovery.
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