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Pluripotent stem cell lines available for use in clinical applications: A comprehensive overview
Melissa K Carpenter1, Tenneille E Ludwig2
1Carpenter Consulting Corporation, Bellingham, WA, USA.
Stem Cell Reports
|December 19, 2025
Summary
Clinically suitable human pluripotent stem cell (hPSC) lines are crucial for developing hPSC-derived products. This study identifies 166 "off-the-shelf" hPSC lines available for licensing to accelerate clinical development.
Area of Science:
- Stem Cell Biology
- Regenerative Medicine
- Biotechnology
Background:
- Human pluripotent stem cell (hPSC) technology has advanced significantly over 25 years.
- hPSC-derived products are increasingly used in clinical trials.
- Developing custom hPSC lines for product manufacturing is time-consuming and resource-intensive.
Purpose of the Study:
- To address the growing need for readily available, clinically suitable hPSC lines.
- To provide a resource for developers seeking
- off-the-shelf
- hPSC lines for product development.
Main Methods:
- Identification of 166 hPSC lines suitable for clinical applications.
- Compilation of details for preliminary developer evaluation.
Main Results:
- 166 clinical hPSC lines identified as available for licensing and distribution.
- Data provided to aid in the selection of appropriate hPSC lines.
Conclusions:
- Accelerated clinical trials necessitate accessible, pre-developed hPSC lines.
- This curated list facilitates the preliminary evaluation and selection of hPSC lines for clinical development.
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