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Energetics and evolution: Response to Martin.

Michael Lynch1

  • 1Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, 85287-7701, United States of America.

Biochimica Et Biophysica Acta. Bioenergetics
|December 19, 2025
PubMed
Summary
This summary is machine-generated.

This study refutes claims of inaccurate bioenergetic cost estimates for cell production. The author

Keywords:
ATPBioenergeticsEukaryotesEvolutionary cell biologyMitochondrion

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Area of Science:

  • Cellular bioenergetics
  • Evolutionary biology
  • Microbial metabolism

Background:

  • Recent research suggested significant overestimation (over 100-fold) in cellular bioenergetic cost calculations.
  • This prior work questioned the foundational understanding of energy expenditure in cell synthesis.

Purpose of the Study:

  • To re-evaluate the accuracy of previous bioenergetic cost estimates for cell production.
  • To address the interpretation of methodologies used in prior bioenergetic studies.
  • To examine the proposed link between mitochondrial establishment and eukaryotic evolutionary leaps.

Main Methods:

  • Critical analysis of methodologies employed in previous bioenergetic cost estimations.
  • Re-interpretation of published data on cellular energy expenditure.
  • Evaluation of evolutionary theory and empirical data concerning eukaryotic innovation.

Main Results:

  • The conclusion of a 100-fold error in bioenergetic cost estimates is based on a misinterpretation of methods.
  • The author's arguments regarding bioenergetic costs are conceptually flawed.
  • Evidence contradicts the claim that mitochondria triggered a revolutionary increase in bioenergetic capacity driving eukaryotic evolution.

Conclusions:

  • Prior estimates of cellular bioenergetic costs are not off by over 100-fold as claimed.
  • The role of mitochondria in eukaryotic innovation is overstated and inconsistent with data.
  • This work corrects a significant misunderstanding in the field of bioenergetics and evolution.