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Updated: Jan 8, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
Published on: May 6, 2009
Do we actually need aging clocks?
Dmitrii Kriukov1,2, Evgeniy Efimov3,4, Mikhail S Gelfand3
1Skolkovo Institute of Science and Technology, Moscow, Russia. kriukov@airi.net.
None:
Aging clocks use machine learning to estimate biological age as a proxy for general health state. Here, we critically examine their practical value, highlighting fundamental challenges: abstract definitions, inconsistent clinical validation, and ignored prediction uncertainty. By comparing aging clocks with expert risk scores, direct outcome predictors, and emerging large health models, we question their benefits and encourage researchers to explicitly justify clock advantage over established alternatives, ensuring truly actionable insights.
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