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Updated: Jan 8, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Changes in Eating Behaviour During Treatment With Obesity Medications
Ming Chuen Chong1, Tak Ying Louise Ko1, Philippus L le Roux1
1Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.
Abstract:
Obesity is a chronic, relapsing disease influenced by biological, environmental and behavioural factors. Pharmacological therapies have demonstrated substantial effects in weight loss, appetite suppression and modulation of food-related thoughts; however, the long-term effects of medications and eating behaviours across treatment phases throughout time remain poorly understood. This qualitative study involves 31 semi-structured interviews exploring patients in the dynamic and stable phase of weight loss. The interviews were conducted, transcribed, then analysed thematically. The five main themes that emerged were hunger, fullness, thoughts of food, portion size and palatability. The dynamic phase reported profound appetite suppression, early fullness, reduced 'food noise' with diminished cravings and smaller portion size. Portion control remained a persistent behavioural change across both phases. Long-term goals shifted from weight loss in the dynamic phase to weight maintenance in the stable phase. This transition is best described as a spectrum of change rather than a strict dichotomy. With a perceived loss of efficacy, some also report consideration of switching medications, especially in the stable phase. Overall, this cross sectional, patient-centred qualitative study may change practice of prescribers, policymakers, and the focus of future research.
Insights
Pharmacological obesity treatments effectively reduce appetite and food cravings. Patients experience weight loss and maintenance as a spectrum, with portion control being a key long-term behavior.
Area of Science:
- Obesity research
- Behavioral science
- Pharmacological interventions
Background:
- Obesity is a complex, chronic disease influenced by multiple factors.
- Pharmacological therapies aid weight loss but long-term effects on eating behaviors are unclear.
Purpose of the Study:
- To explore patient experiences with weight loss medications and eating behaviors during dynamic and stable phases.
- To understand the transition from weight loss to weight maintenance.
Main Methods:
- Qualitative study utilizing 31 semi-structured interviews.
- Thematic analysis of interviews focusing on hunger, fullness, food thoughts, portion size, and palatability.
Main Results:
- Dynamic phase: profound appetite suppression, early fullness, reduced food noise, smaller portions.
- Portion control is a persistent behavioral change across phases.
- Long-term goals shift from weight loss to maintenance; medication efficacy concerns arise in the stable phase.
Conclusions:
- Weight management is a spectrum, not a dichotomy.
- Patient-centered insights can inform clinical practice, policy, and future research on obesity pharmacotherapy.
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