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Updated: Jan 8, 2026
Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
First successful protocol for desensitization to eptinezumab
Benoit Gerard1, Hubert Praudel1, Michel Lanteri-Minet2,3
1Département de pneumologie et d'oncologie thoracique, Centre Hospitalier Universitaire de Nice, IHU RespirERA, Université Côte d'Azur, Nice, France.
Background:
Eptinezumab is an anti-calcitonin gene-related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E-mediated, the team of Nice University Hospital (Nice, France) performed the eptinzeumab skin tests. A 10-step desensitization protocol has been proposed to manage these reactions.
Findings:
Two patients presenting with immediate hypersensitivity reactions underwent the eptinezumab skin test. Neither skin test was positive, suggesting a non-immunoglobulin E-mediated mechanism. The patients then completed the desensitization protocol successfully.
Conclusion:
This hospital-based 10-step desensitization protocol appears safe and effective.
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