Related Experiment Video
Updated: Jan 8, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Natural Compounds as Nephroprotective Agents: Therapeutic Potential Against Drug-Induced Kidney Injury
Mukul Shyam1, Abantika Pal1, Dishari Dey1
1Department of Biotechnology, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.
Drug-induced nephrotoxicity, a major cause of acute kidney injury, necessitates better treatments. Phytochemicals and novel biomarkers show promise for protecting kidneys and improving early detection of drug-induced kidney damage.
Area of Science:
- Nephrology
- Pharmacology
- Biochemistry
Background:
- Drug-induced nephrotoxicity is a significant clinical problem, causing 19-26% of acute kidney injury cases.
- Kidneys are vulnerable to xenobiotics due to their role in drug metabolism and excretion.
- Current treatments are supportive, relying on insensitive biomarkers like serum creatinine.
Purpose of the Study:
- To review nephroprotective phytochemicals and novel diagnostic biomarkers for drug-induced kidney injury.
- To explore nanotechnology-based delivery systems for enhanced therapeutic efficacy.
Main Methods:
- Narrative review of existing literature on nephroprotective agents and biomarkers.
- Examination of mechanisms of drug-induced nephrotoxicity.
- Analysis of experimental data on phytochemicals and novel biomarkers.
Main Results:
- Phytochemicals (e.g., quercetin, resveratrol) exhibit antioxidant, anti-inflammatory, and anti-apoptotic properties beneficial for kidney protection.
- Novel biomarkers (e.g., NGAL, KIM-1) offer enhanced diagnostic accuracy for early renal injury.
- Nanotechnology holds potential for improving the delivery and efficacy of nephroprotective agents.
Conclusions:
- There is a critical need for effective nephroprotective strategies and reliable early diagnostic indicators for drug-induced kidney injury.
- Phytochemicals and advanced biomarkers represent promising avenues for managing and diagnosing nephrotoxicity.
- Integrating nanotechnology may further optimize therapeutic outcomes in preventing and treating kidney damage from medications.
More Related Videos
06:38Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
07:15Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Heart Failure Drugs: Diuretics
Acute Kidney Injury V: Interprofessional Care
Antihypertensive Drugs: Potassium-Sparing Diuretics
Drug Elimination by Renal Route: Tubular Secretion
Drug Elimination by Renal Route: Tubular Reabsorption