Related Experiment Video
Updated: Jan 8, 2026

Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
Kratom (Mitragyna speciosa) as a Replacement for Alcohol Among a Sample of Malaysian Adults with a History of Alcohol
Darshan Singh1, Devasharmini Mathandaver1, Christian P Müller2
1Centre for Drug Research, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Background:
Kratom (Mitragyna speciosa) is traditionally used for its medicinal value in Southeast Asia. While kratom is used as a substitute for narcotics, its utility remains unstudied among alcohol users. We determined the context and motives of kratom use in a sample who have used kratom to manage their alcohol use problem.
Method:
Sixteen respondents who claimed to have used kratom to self-treat their alcohol use problem were recruited for this qualitative study. All the in-depth interviews were thematically analyzed.
Results:
All males, and their mean age was 58.6 years (SD = 6.67). Kratom was ingested as a substitute for alcohol and to self-treat alcohol use problem. Kratom was shown to have the potential to reduce alcohol dependence, since there was a pronounced reduction in the frequency and intake (quantity) of alcohol use. Cessation from alcohol use occurred relatively fast, since respondents took about 1 to 3 months to abstain from it completely. No one has relapsed to alcohol use since initiating kratom. Despite having used kratom regularly, none stated to have developed dependence on it. While alcohol affected social functioning, conversely, kratom did not do so.
Conclusions:
Our findings highlight that kratom was being consumed as a substitute for alcohol and suggests its potential utility to reduce or cease alcohol consumption. However, further longitudinal studies are needed to confirm this finding.
More Related Videos
08:05A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
Published on: January 5, 2018
05:12Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug Dependence
Radical Oxidation of Allylic and Benzylic Alcohols
Preparation of Alcohols via Substitution Reactions
Alcohols can be synthesized from alkyl halides via nucleophilic substitution reactions. The highly polar carbon-halogen bond in the substrate makes halide a good leaving group. The hydroxide ion or water can act as a nucleophile to take the place of halide and form an alcohol. The substitution reactions occur via two different reaction pathways, SN1 or SN2, depending on the nature of carbon attached to the halide.
Primary alcohols are synthesized from primary alkyl halides, and the...