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Surgery in NF2-Schwannomatosis.

Michel Kalamarides1,2, Omar Pathmanaban3,4, Matthieu Peyre5,6

  • 1Sorbonne Université, Groupe Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France. michel.kalamarides@aphp.fr.

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|December 20, 2025
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Summary

NF2-Schwannomatosis (NF2-SWN) involves multiple nervous system tumors. This review details therapeutic indications for various tumor types and emphasizes multidisciplinary team experience and centralized care for improved patient outcomes.

Keywords:
NF2- related schwannomatosisNF2-SWNEpendymomaGenetic predispositionMeningiomaPeripheral schwannomaSkull base neoplasmSpinal schwannomaVestibular schwannoma

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Area of Science:

  • Neuro-oncology
  • Genetics
  • Neurosurgery

Background:

  • NF2-Schwannomatosis (NF2-SWN) is a rare genetic disorder.
  • Characterized by the development of multiple tumors in the central and peripheral nervous system.
  • Tumor types include vestibular schwannomas, meningiomas, spinal ependymomas, and peripheral schwannomas.

Purpose of the Study:

  • To provide a comprehensive review of therapeutic indications for various tumor types in NF2-SWN.
  • To highlight the importance of a multidisciplinary team approach in managing this complex disease.
  • To discuss the impact of centralized care on patient outcomes.

Main Methods:

  • Literature review focusing on therapeutic strategies for NF2-SWN.
  • Analysis of treatment indications based on tumor type and patient-specific factors.
  • Discussion of the role of multidisciplinary teams and centralized care models.

Main Results:

  • Specific therapeutic indications are detailed for vestibular schwannomas, meningiomas, spinal schwannomas and meningiomas, spinal ependymomas, and peripheral schwannomas.
  • Individualized treatment planning is crucial due to unique patient disease burden.
  • Multidisciplinary team expertise significantly impacts patient outcomes.

Conclusions:

  • Effective management of NF2-SWN requires tailored treatment strategies for each tumor type.
  • Centralized care and experienced multidisciplinary teams are essential for optimizing patient care and disease course in NF2-SWN.