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Surgery in NF2-Schwannomatosis
Michel Kalamarides1,2, Omar Pathmanaban3,4, Matthieu Peyre5,6
1Sorbonne Université, Groupe Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France. michel.kalamarides@aphp.fr.
Familial Cancer
|December 20, 2025
Summary
NF2-Schwannomatosis (NF2-SWN) involves multiple nervous system tumors. This review details therapeutic indications for various tumor types and emphasizes multidisciplinary team experience and centralized care for improved patient outcomes.
Area of Science:
- Neuro-oncology
- Genetics
- Neurosurgery
Background:
- NF2-Schwannomatosis (NF2-SWN) is a rare genetic disorder.
- Characterized by the development of multiple tumors in the central and peripheral nervous system.
- Tumor types include vestibular schwannomas, meningiomas, spinal ependymomas, and peripheral schwannomas.
Purpose of the Study:
- To provide a comprehensive review of therapeutic indications for various tumor types in NF2-SWN.
- To highlight the importance of a multidisciplinary team approach in managing this complex disease.
- To discuss the impact of centralized care on patient outcomes.
Main Methods:
- Literature review focusing on therapeutic strategies for NF2-SWN.
- Analysis of treatment indications based on tumor type and patient-specific factors.
- Discussion of the role of multidisciplinary teams and centralized care models.
Main Results:
- Specific therapeutic indications are detailed for vestibular schwannomas, meningiomas, spinal schwannomas and meningiomas, spinal ependymomas, and peripheral schwannomas.
- Individualized treatment planning is crucial due to unique patient disease burden.
- Multidisciplinary team expertise significantly impacts patient outcomes.
Conclusions:
- Effective management of NF2-SWN requires tailored treatment strategies for each tumor type.
- Centralized care and experienced multidisciplinary teams are essential for optimizing patient care and disease course in NF2-SWN.
