Related Experiment Video
Updated: Jan 7, 2026
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8+ T Cell Function in the Context of
Paulina Kwaśnik1, Martyna Stępień1, Katarzyna Skórka1
1Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland.
Abstract:
This study evaluated the immune surveillance function in chronic myeloid leukemia (CML) through tumor antigen gene expression analysis, in vitro mixed lymphocyte cultures with peptides, and immunological analysis of patients after imatinib withdrawal to investigate factors affecting treatment-free remission (TFR). Specific immune responses were demonstrated in T lymphocytes against SPAG9 and NY-REN-60 peptides, highlighting their potential in immunotherapy. Immune profiling identified that CD8+PD1+, CD56dimCD16+PD1+, and iNKT+CD161+ cells contribute to recurrence-free survival. A Cox model confirmed the prognostic value of immune markers. These results emphasize the critical role of the immune system in CML and indicate novel targets for sustaining TFR.
More Related Videos
07:36Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
09:57Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
Published on: January 29, 2019
