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Updated: Jan 8, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Published on: September 13, 2018

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PRSS23 promotes pancreatic cancer progression through regulating Hippo-YAP activity

Zhihong Liu1, Qiuping Jiang2, Yuanmeng Sun1

  • 1Central Laboratory, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, 225300, China.

Biochemical and Biophysical Research Communications
|December 20, 2025
PubMed
Summary

PRSS23 is a key driver of pancreatic cancer (PDAC) progression. Inhibiting PRSS23 may offer a new therapeutic strategy for PDAC by disrupting the Hippo signaling pathway and YAP activation.

Keywords:
HippoPRSS23Pancreatic ductal adenocarcinomaYAP

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