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Risk of short telomere as biomarker of diabetes mellitus type 2 status in the CORDIOPREV study.

Ana Ojeda-Rodriguez1, Maria Jose Parraga-Viudez1, Juan L Romero-Cabrera1

  • 1Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, 14004 Córdoba, Spain; Department of Medical and Surgical Science, University of Cordoba, 14004 Córdoba, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Av. Menendez Pidal, s/n, 14004 Cordoba, Spain; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|December 20, 2025
PubMed
Summary
This summary is machine-generated.

Shorter telomere length (TL) is linked to type 2 diabetes mellitus (T2DM) in patients with coronary heart disease (CHD). This cellular aging marker may help predict T2DM risk in secondary prevention strategies.

Keywords:
Cellular agingCoronary heart diseaseEnfermedad coronariaEnvejecimiento celularIntervención en estilo de vidaLifestyle interventionPrevención secundariaSecondary prevention

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Area of Science:

  • Cardiology
  • Endocrinology
  • Gerontology

Background:

  • Type 2 diabetes mellitus (T2DM) worsens outcomes in cardiovascular disease (CVD) patients.
  • Biomarker identification is crucial for predicting T2DM onset and progression in secondary prevention.
  • Telomere length (TL), a marker of cellular aging, is implicated in oxidative stress, inflammation, and metabolic dysfunction.

Purpose of the Study:

  • To assess TL as a potential biomarker for T2DM in patients with coronary heart disease (CHD).

Main Methods:

  • 956 patients from the CORDIOPREV study with available TL data were analyzed.
  • Participants were categorized by diabetes status post-intervention: 407 T2DM-free, 549 with T2DM.
  • TL was quantified using qPCR; short telomeres were defined as below the 20th percentile.

Main Results:

  • T2DM patients exhibited significantly shorter TL (1.26±0.74) than non-T2DM patients (1.38±0.84; p=0.026).
  • Each 1-SD increase in TL correlated with a 17% reduced T2DM risk (OR 0.83).
  • Short TL (<20th percentile) was associated with a higher T2DM prevalence (20% vs. 17%; p=0.035) and increased risk (OR 1.42). TL, age, BMI, insulin, triglycerides, and HbA1c were independent T2DM predictors. Short TL remained associated with T2DM risk after adjusting for fasting glucose (OR 1.57, p=0.049).

Conclusions:

  • Shorter TL is significantly associated with the presence of T2DM in patients with CHD.
  • TL demonstrates potential as an independent biomarker for T2DM risk assessment in secondary prevention settings.