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Updated: Jan 7, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Clinical characteristics of extremely elderly versus normal elderly patients with chronic limb-threatening ischemia:
Ke Wang1, Haijun Wei1, Qiqi Wang1
1Department of Vascular Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Background:
The benefit of endovascular therapy (EVT) for chronic limb-threatening ischemia (CLTI) in patients aged ≥ 80 years (extremely elderly) is debated. This study compared outcomes between extremely elderly and younger elderly (60-79 years) patients.
Methods:
In this retrospective study, 367 patients (133 ≥ 80y, 234 60-79y) undergoing EVT were analyzed. Propensity score matching balanced baseline characteristics. Primary endpoints were one-year major adverse limb events (MALEs) and mortality. Univariate Cox analysis identified MALE-associated factors.
Results:
After matching, the ≥ 80y group had more complex lesions (longer occlusions, poorer runoff). Their one-year freedom from MALEs (44.721% vs 61.697%, p = 0.053) and freedom from mortality rates(77.191% vs 85.628%, p = 0.215) were lower. Univariate analysis indicated age ≥ 80y (HR = 1.55, 95% CI 1.01-2.38, P = 0.043) and TASC II C/D lesions (HR = 1.26, 95% CI 1.02-1.55, P = 0.035) increased MALE risk, while drug-coated balloons((HR = 0.69, 95% CI 0.56-0.85, P = 0.001). and Lipid lowering agents usage (HR = 0.59, 95% CI 0.36-0.98, P = 0.041) were protective. Postoperative psychiatric symptoms were more frequent in the ≥ 80y group. Critically, both groups showed significant and comparable improvements in pain scores and functional capacity after EVT.
Conclusions:
Despite higher risks, EVT meaningfully improves quality of life in extremely elderly CLTI patients. Treatment should not be denied based on age alone, but should be individualized considering the higher anatomical complexity.
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