Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

711
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
711
Determination of Pi Terms01:15

Determination of Pi Terms

567
The Buckingham Pi theorem is a valuable method in dimensional analysis, reducing complex relationships between variables into dimensionless terms. Relevant variables in analyzing the lift force on an airplane wing include lift force, air density, wing area, aircraft velocity, and air viscosity. Expressing each variable in terms of fundamental dimensions — mass, length, and time — provides a consistent foundation for constructing these dimensionless terms.
The theorem indicates that the...
567

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary fibrosis after COVID-19 is characterized by airway abnormalities and elevated club cell secretory protein-16.

JCI insight·2026
Same author

Risk prediction for lung cancer screening: a systematic review and meta-regression.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.

Ethnicity & disease·2026
Same author

Deep learning-based CT-derived vertebral bone mineral density and metformin therapy: a longitudinal study in the Multi-Ethnic Study of Atherosclerosis.

Skeletal radiology·2026
Same author

CT Emphysema and Deep Learning-derived Vertebral Bone Loss in Individuals without COPD: Findings from MESA.

Radiology·2026
Same author

The Impact of Neighborhood Material and Social Disadvantage on Respiratory Health Across Canada.

The European respiratory journal·2026

Related Experiment Video

Updated: Jan 8, 2026

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
08:46

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation

Published on: July 26, 2017

13.8K

Comparison of Pi10 and PiSlope calculation methods and association with lung function.

Razieh Enjilela1, Sukhraj Virdee1, Jason Bartlett1

  • 1Physics Department, Toronto Metropolitan University, Toronto, ON, Canada.

European Radiology
|December 21, 2025
PubMed
Summary
This summary is machine-generated.

This study found that calculation methods for CT airway remodeling biomarkers (Pi10 and PiSlope) that include more airways are more reliable. PiSlope showed stronger associations with lung function in COPD patients.

Keywords:
Airway remodelingCOPDCTPi10PiSlope

More Related Videos

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.9K
Measurement of the Pressure-volume Curve in Mouse Lungs
09:49

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

19.3K

Related Experiment Videos

Last Updated: Jan 8, 2026

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation
08:46

A Standardized Method for Measuring Internal Lung Surface Area via Mouse Pneumonectomy and Prosthesis Implantation

Published on: July 26, 2017

13.8K
Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.9K
Measurement of the Pressure-volume Curve in Mouse Lungs
09:49

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

19.3K

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Biomarker Discovery

Background:

  • Computed tomography (CT) derived Pi10 and PiSlope are biomarkers for airway remodeling in chronic obstructive pulmonary disease (COPD).
  • Variability in calculation methods for Pi10 leads to inconsistent results across studies.

Purpose of the Study:

  • To evaluate the reliability of 10 different methodologies for calculating Pi10 and PiSlope.
  • To assess the association of these methodologies with lung function in COPD patients.

Main Methods:

  • Ten literature-based methods were used to calculate Pi10 and PiSlope from CT scans of 1351 COPD participants.
  • Reliability was assessed using intraclass correlation (ICC).
  • Associations with lung function (FEV1, FEV1/FVC, FEF25-75%) were evaluated using regression analysis.

Main Results:

  • Methods incorporating a higher number of airways demonstrated excellent reliability (ICC > 0.90).
  • PiSlope consistently showed stronger negative associations with lung function parameters compared to Pi10 across all methods.
  • These associations were particularly pronounced in participants with fewer analyzed airways.

Conclusions:

  • CT-derived Pi10/PiSlope calculation methods that include more airways offer greater reliability.
  • PiSlope may serve as a more comprehensive and reliable biomarker for assessing airway remodeling in COPD.
  • Findings aid in standardizing interpretations and support PiSlope's clinical utility.