Antigenicity testing of plain and aluminium hydroxide-adsorbed whole-cell cholera vaccines

The antigenicity of a plain and of an aluminium hydroxide-adsorbed whole-cell cholera vaccine was investigated by the active mouse protection test and the vibriocidal antibody production assay in mice. In the active mouse protection test, between the antigenicity of the Inaba and Ogawa component of the two vaccines was no significant difference. The antibody production test, however, revealed that the adsorbed vaccine elicited higher and longer lasting immune response than the plain one. The antibody response to a two-dose immunization schedule was substantially superior to that after a one-dose schedule.