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Simple lithium measurement in capillary dried plasma microsamples collected with the HealthID PSD device
Eduarda Milena Reichert1, Carolina Weber Ferrareze1, Mayara Bernardes1
1Laboratory of Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Clinical Biochemistry
|December 21, 2025
Summary
A new method accurately measures lithium levels in dried plasma spots (DPS) using capillary blood, simplifying bipolar disorder treatment monitoring. This minimally invasive technique offers stable and reliable results for patient care.
Area of Science:
- Clinical Chemistry
- Analytical Chemistry
- Pharmacology
Background:
- Monitoring serum lithium is crucial for effective bipolar disorder treatment.
- Current methods can be invasive and require frequent venipuncture.
- A simpler, less invasive method for lithium monitoring is needed.
Purpose of the Study:
- To develop and validate a simple method for estimating serum lithium concentrations using dried plasma spots (DPS).
- To assess the reliability and accuracy of DPS for lithium monitoring compared to traditional serum samples.
Main Methods:
- Developed a method using capillary blood on the HealthID PSD device to create DPS.
- Extracted lithium from DPS using BSA solution and quantified via colorimetric assay.
- Applied chloride correction for plasma volume variability and validated analytically and clinically against serum samples.
Main Results:
- The method demonstrated linearity from 0.1-2.5 mmol/L with high extraction yields (93.2-95.7%).
- Chloride correction improved precision; hematocrit and volume had minimal effects.
- DPS lithium showed strong correlation (r=0.984) with serum, with low predictive errors (MPPE 0.91%, MAPE 6.7%).
Conclusions:
- Lithium can be reliably quantified in DPS from the HealthID PSD device using a standard colorimetric assay.
- This method provides a stable, minimally invasive approach for clinical lithium therapy monitoring.
