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Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
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Complement Inhibition in Immunoglobulin A Nephropathy: A Mini-Review

Jia Wei Teh1, Sinead Stoneman2, Michelle M O'Shaughnessy1

  • 1School of Medicine, University of Galway, Galway, Ireland; Department of Nephrology, University Hospital Galway, Galway, Ireland.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 21, 2025
PubMed

IgA nephropathy (IgAN) is the most common immune-mediated glomerular disease worldwide. Advanced understanding of the role of complement in IgAN pathogenesis has motivated the development of complement inhibition as a therapeutic strategy. Iptacopan, a complement factor B inhibitor, is the first approved complement inhibitor for IgAN. Several other complement inhibitors are being studied in phase 2/3 clinical trials. How best to integrate complement inhibition into the evolving treatment paradigm for IgAN remains a challenge. This review provides an overview of the role of complement in the pathogenesis and progression of IgAN and summarizes current and emerging complement-targeted IgAN therapies.

Keywords:
ComplementIgA nephropathyglomerular diseasereview

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