Bisphosphonate Use and Reduced All-Cause Mortality in Korean Women Older than 50 Years: A Nationwide Sample Cohort
Soon Young Park1, Jisoo Lee1, Youjin Lee2
1Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Background:
The survival impact of bisphosphonates (BPs) remains uncertain, particularly in East Asian populations, where new-user analyses have been limited.
Methods:
This was a retrospective, new-user cohort study using the Korean National Health Insurance Service-National Sample Cohort (2002-2011). We identified new users of BPs (N=41,854), and a 1:1 age-matched control group (N=41,854) among women aged ≥ 50 years. Participants were followed for all-cause mortality for up to 10 years. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs), adjusting for age and the Charlson Comorbidity Index.
Results:
A total of 83,708 women were included. Compared with the control group, the risk of all-cause mortality was lower in BP group. BP users showed adjusted HR of 0.47 (95% confidence interval, 0.44-0.49; P<0.001) compared to controls.
Conclusions:
In this large, nationwide Korean cohort, initiating BPs was associated with a reduced risk of all-cause mortality in women aged 50 and older. These findings suggest that BPs may have survival benefits beyond fracture prevention.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
01:15Drug Dosing: Geriatric Patients
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion