Diagnostic and prognostic values of the systemic immune-inflammation index in children with immune thrombocytopenia
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Shiyi Hu1, Wenyong Kuang1, Wanli Li1
1Department of Hematology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) Changsha, Hunan, China.
Insights
The systemic immune inflammation (SII) index is lower in children with immune thrombocytopenia (ITP). This index helps predict ITP occurrence and recurrence within two years, aiding diagnosis and prognosis.
Area of Science:
- Hematology
- Immunology
- Pediatrics
Background:
- The diagnostic and prognostic value of the systemic immune inflammation (SII) index in immune thrombocytopenia (ITP) requires further investigation.
- ITP is a condition affecting platelet counts, with potential for recurrence.
Purpose of the Study:
- To evaluate the diagnostic and prognostic significance of the SII index in pediatric immune thrombocytopenia.
- To determine if SII can predict ITP occurrence and recurrence in children.
Main Methods:
- Retrospective analysis of 120 ITP children and 79 healthy controls.
- Categorization of ITP patients into recurrence and non-recurrence groups based on 2-year post-treatment outcomes.
- Application of multivariate Cox regression and survival analysis (Kaplan-Meier curves, ROC curves).
Main Results:
- Children with ITP showed significantly lower SII index values compared to healthy controls.
- The SII index was found to be a significant predictor of ITP occurrence and recurrence within two years.
- Platelet count and SII were identified as independent protective factors against disease recurrence in ITP patients.
Conclusions:
- The SII index is reduced in pediatric ITP patients, suggesting its utility in diagnosis.
- The SII index demonstrates strong predictive value for the risk of disease recurrence within two years post-treatment in children with ITP.
Background:
The diagnostic and prognostic value of the systemic immune inflammation (SII) index for immune thrombocytopenia (ITP) remains to be determined.
Research Design And Methods:
A retrospective analysis was conducted on 120 ITP children admitted to The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) between January 2017 and June 2022. A control group comprised 79 healthy children undergoing outpatient physical examinations during the same period. Based on recurrence within 2 years post-treatment, ITP children were categorized into recurrence and non-recurrence groups. Multivariate Cox regression analysis was conducted, and receiver operating characteristic curves and Kaplan-Meier curves were plotted.
Results:
ITP children exhibited significantly reduced SII. The SII index assisted in predicting ITP occurrence and recurrence within 2 years post-treatment. PLT count and SII were independent protective factors against disease recurrence within 2 years post-treatment in ITP patients. A decrease in SII increased the risk of disease recurrence within 2 years.
Conclusions:
ITP children exhibit reduced SII index. The SII index can assist in the diagnosis of ITP and demonstrates strong predictive value for disease recurrence risk within 2 years post-treatment in ITP children.
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