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Posterior Fossa Group A Ependymoma in Trisomy 21

Yuta Fujimoto1,2, Hirotaka Inoue1, Jun-Ichiro Kuroda1

  • 1Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|December 21, 2025
PubMed

Insights

Trisomy 21 may reduce the risk of certain pediatric brain tumors, including ependymoma. Further research into this protective role could improve understanding and treatment of these rare conditions.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Genetics

Background:

  • Brain tumors are the most common solid tumors in children.
  • Individuals with trisomy 21 (Down syndrome) show a reduced risk of central nervous system tumors.
  • Ependymoma is a type of brain tumor that can occur in children.

Keywords:
brain tumorependymomaposterior fossa group a (PFA)trisomy 21

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