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Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Acute promyelocytic leukemia complicated by osteofascial compartment syndrome
Xiaojuan Li1, Min Liu1, Zhan Su1
1Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background:
Osteofascial compartment syndrome (OCS) refers to a series of clinical syndromes caused by acute ischemia and hypoxia of the tissues inside a fascial compartment. OCS secondary to acute leukemia is extremely rare. Coagulopathy is a common phenomenon in acute promyelocytic leukemia (APL), which often leads to various bleeding complications.
Clinical Presentation:
We report the first case of APL complicated by OCS. The elderly female experienced differentiation syndrome, left forearm OCS, and rhabdomyolysis during the induction treatment. The coagulopathy ultimately resulted in a fatal cerebral hemorrhage.
Conclusion:
Compared to the more commonly reported OCS associated with chronic leukemias, OCS secondary to APL is particularly perilous.
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