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Unraveling the Significance of Fecal MicroRNA Profile in Alzheimer's Disease

Kavisha Katuwawala1,2, Prashant Bharadwaj1,2, Ian Martins1,2

  • 1Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.

Molecular Neurobiology
|December 21, 2025
PubMed

Insights

Fecal microRNAs and gut microbiota, influenced by diet, show promise for early Alzheimer's disease detection. This review explores their role as non-invasive indicators for intervention strategies.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Genetics

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide.
  • Current treatments focus on symptom management; early detection is critical for intervention.
  • Fecal microRNA (miRNA) analysis offers a promising non-invasive diagnostic approach for AD.

Purpose of the Study:

  • To review the interplay between diet-modulated fecal miRNAs and gut microbiota in Alzheimer's disease.
  • To explore their potential as novel, non-invasive indicators for early AD detection and intervention.

Main Methods:

  • Literature review focusing on diet, gut microbiota, fecal miRNAs, and Alzheimer's disease.
  • Analysis of mechanisms linking dietary factors to gut microbiota composition and miRNA expression.
  • Examination of the gut-brain axis in the context of AD pathology.

Main Results:

  • Dietary components significantly influence gut microbiota and miRNA expression.
  • Specific miRNAs in fecal samples correlate with AD pathology and gut-brain axis function.
  • High-fat diets are associated with increased inflammation and AD risk.

Conclusions:

  • Diet-modulated fecal miRNAs and gut microbiota represent potential non-invasive biomarkers for early AD detection.
  • Understanding this interplay can inform novel intervention strategies for Alzheimer's disease.
  • Further research is warranted to validate these indicators for clinical application.
Keywords:
Alzheimer’s disease (AD)Gut microbiotaGut–brain axisMicroRNAs (miRNAs)

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