Assessment of Hyaluronic Acid Filler in Gluteal Augmentation and Contouring: A 1-Year Prospective Study

Minimally invasive gluteal augmentation techniques have gained popularity as alternatives to surgical procedures, offering reduced downtime and an improved safety profile. Hyaluronic acid (HA) fillers have emerged as a promising option due to their biocompatibility and favorable rheological characteristics.

To evaluate safety, efficacy, durability, and patient satisfaction of a cross-linked HA filler for gluteal augmentation and contouring over a 12-month period, and to conduct a pilot exploratory substudy assessing serum HA levels up to 90 days.

This was a 12-month, prospective, multicenter, open-label study including 30 healthy women undergoing gluteal augmentation with a cross-linked HA filler (UP Max). Each participant received up to 60 mL of HA filler, administered using a quadrant-based technique, guided by anatomical landmarks. Outcomes included safety (adverse events), efficacy (standardized photography and 3D imaging, ultrasound), durability and patient satisfaction. In addition, serum HA levels were measured in a pilot subgroup of patients.

The mean injected volume was 43.60 ± 11.48 mL. Patient satisfaction peaked at Day 30 (90%) and declined to 62% at 12 months, consistent with HA biodegradation. Ultrasound confirmed subcutaneous placement and progressive filler absorption and integration, with no signs of migration, fibrosis or nodularity. Serum HA levels showed a transient increase at Day 30 and returned to near baseline at Day 90. No serious adverse events were reported, and minor complications were infrequent.

HA filler demonstrated a favorable safety profile, high patient satisfaction, and aesthetic improvements over 1 year. These findings support its use as a safe and effective option for nonsurgical gluteal augmentation and body contouring.