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Understanding the Compatibility of Fluoride-Based Radiopharmaceutical Reaction Solutions and PDMS.

Mark Mc Veigh¹, Charles Frech², Mai Lin^3,4

¹Interdisciplinary Materials Science, Vanderbilt University, Nashville, Tennessee 37235, United States.

ACS Applied Materials & Interfaces

|December 22, 2025

Summary

This summary is machine-generated.

Polydimethylsiloxane (PDMS) microfluidic devices show incompatibility with fluoride-18 (¹⁸F) and potassium carbonate, especially upon salt crystallization. This confirms PDMS should be avoided in most radiofluorination applications.

Keywords:

PDMS compatibility fluoride microfluidics radiopharmaceuticals

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Area of Science:

Radiopharmaceutical Manufacturing
Microfluidics
Materials Science

Background:

Microfluidic devices are increasingly used in radiopharmaceutical manufacturing.
Polydimethylsiloxane (PDMS) is a common microfluidic material but its compatibility with Fluorine-18 (¹⁸F) is debated.

Purpose of the Study:

To investigate the interaction between fluoride and PDMS.
To clarify the incompatibility of PDMS with ¹⁸F radiofluorination.

Main Methods:

Scanning Electron Microscopy (SEM) imaging
Profilometry
Gas Chromatography-Mass Spectrometry (GC-MS)

Main Results:

SEM and profilometry confirmed a reactive relationship between PDMS and crystallized salts from reaction solutions.
GC-MS identified fluoride-containing volatile species and PDMS incompatibility with potassium carbonate (K₂CO₃).
Interaction occurs primarily when reaction solutions fully evaporate and crystallized salts contact PDMS.

Conclusions:

PDMS is incompatible with ¹⁸F radiofluorination processes involving salt crystallization.
Microfluidic devices for radiofluorination should generally avoid PDMS.
PDMS may still be suitable for liquid-phase microfluidic operations like concentration and purification.