Related Experiment Video

Updated: Jan 8, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Dose optimization of linezolid among surgical patients: A population pharmacokinetic study

Mustajab Ali Naseer, Muhammad Aamir, Hajira Bilal

    International Journal of Clinical Pharmacology and Therapeutics
    |December 22, 2025
    PubMed
    Abstract

    Insights

    Linezolid dosing should be adjusted based on patient age and kidney function. This pharmacokinetic study recommends specific linezolid doses for varying creatinine clearance levels to ensure effective treatment.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Pharmacy

    Background:

    • Linezolid is a crucial antibiotic for treating severe MRSA and VRE infections.
    • It has a narrow therapeutic index, requiring careful dosing.
    • Linezolid is eliminated via renal and hepatic pathways.

    Purpose of the Study:

    • To develop a population pharmacokinetic model for linezolid.
    • To identify significant covariates affecting linezolid pharmacokinetics.
    • To optimize linezolid dosing strategies based on patient characteristics.

    Main Methods:

    • Population pharmacokinetic modeling using NONMEM software.
    • Analysis of 347 plasma samples from 94 patients.
    • Stepwise covariate modeling to identify influencing factors.

    Main Results:

    • A one-compartment model with first-order elimination was established.
    • Linezolid clearance (CL) was estimated at 3.38 L/h; volume of distribution (Vd) was 36 L.
    • Creatinine clearance (CrCl) and patient age significantly impacted linezolid CL.

    Conclusions:

    • Renal status and age are key covariates for linezolid CL.
    • Recommended linezolid doses: 200 mg (CrCl 20 mL/min), 300 mg (CrCl 40 mL/min), 400 mg (CrCl 80 mL/min), 600 mg (CrCl 120 mL/min).

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