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Bond-Centric Modifications of Hyaluronic Acid: Synthesis, Processing, and Biomedical Applications.
Anqi Yang1, Pu Yang1, Naisi Shen1
1Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People's Republic of China.
International Journal of Nanomedicine
|December 22, 2025
Summary
Hyaluronic acid (HA) modifications enhance its clinical use. This review details chemical bonding strategies and biomedical applications, offering insights for future HA product development.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and biodegradability.
- Natural HA has limitations, driving research into modified HA for improved clinical applications.
Purpose of the Study:
- To review common methods for modifying hyaluronic acid (HA).
- To focus on chemical modification strategies based on resultant chemical bonds.
- To organize HA chemistry by bond types and refine design rules for linking chemistry.
Main Methods:
- Discussion of physical and chemical modification techniques.
- Detailed analysis of chemical modification strategies based on bond types.
- Systematic organization of HA chemistry by bond characteristics.
Main Results:
- Refined design rules for HA linking chemistry considering degradability, mechanical properties, responsiveness, and safety.
- Summary of current applications of HA-based products in ophthalmology, bone/joint treatment, aesthetic medicine, wound healing, and drug delivery.
Conclusions:
- Modified HA offers improved properties for diverse biomedical applications.
- Exploration of challenges and future research directions for clinical HA applications.
