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Regular caffeine consumption & subjective sleep quality: A systematic review.

Duc Minh Phan¹, My Yen Lam¹, Minh Nguyet Trang¹

¹Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh city, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh city, Vietnam.

|December 22, 2025

Summary

Long-term caffeine intake shows weak links to sleep quality. More research is needed to understand caffeine

Keywords:

Caffeine Regular caffeine consumption Sleep Subjective sleep quality Systematic review

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Area of Science:

Nutritional Neuroscience
Sleep Medicine

Background:

Caffeine is the most widely consumed stimulant globally, often used to counteract fatigue.
The relationship between chronic caffeine consumption and subjective sleep quality remains unclear.

Purpose of the Study:

To systematically review the existing literature on the association between long-term caffeine intake and subjective sleep quality.
To identify factors influencing the observed relationship and highlight gaps in current research.

Main Methods:

A comprehensive literature search was conducted, screening 6,908 studies.
Ten studies meeting specific inclusion criteria were selected for the final analysis.

Main Results:

Limited statistically significant associations were found between long-term caffeine consumption and subjective sleep quality.
Variability in study quality, data collection, and assessment methods, along with individual differences and study heterogeneity, hindered clear conclusions.

Conclusions:

The current evidence base is insufficient to establish a definitive link between caffeine and sleep quality due to methodological inconsistencies.
Future research should focus on standardized methodologies and explore genetic, cultural, and timing factors to elucidate caffeine's complex effects on sleep.