Related Experiment Video
Updated: Jan 8, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Ulcero-granulomatous donovanosis in a HIV positive male
Vibhu Mendiratta1, Deepika Yadav1, Surabhi Sinha1
1Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Abstract:
We report the case of a 29-year-old HIV-positive male on antiretroviral therapy who presented with multiple pinhead-sized papules that progressed into varying-sized ulcers over the penile shaft and glans penis. The patient had a history of both protected and unprotected sexual encounters. Recent contact tracing led to the treatment of some partners, although several could not be traced due to residing in distant areas. The patient had a history of recurrent herpes genitalis for the past 4-5 years, with frequent outbreaks. Laboratory findings revealed a CD4 count of 677 cells/mm3 and the patient tested negative for hepatitis B, hepatitis C, VDRL, and TPHA. Diagnosis of donovanosis was confirmed by Giemsa staining, which revealed Donovan bodies. This case highlights the importance of early diagnosis, partner tracing, and comprehensive treatment strategies in managing donovanosis in HIV-positive individuals.
Related Concept Videos
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Sexually Transmitted Infections
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

