Premalignant lesion over glans penis treated with neodymium:yttrium-aluminum-garnet laser

Penile intraepithelial neoplasia (PeIN) is now the new term for premalignant penile skin lesions. It is psychologically devastating to the patient and can pose a challenge to clinicians in the diagnosis. Risk factors for the development of PeIN include phimosis, uncircumcised state, poor genital hygiene, human papillomavirus infection, and smoking. When the condition is more advanced, inguinal lymphadenectomy may be needed, which has considerable morbidity. These lesions are classified separately as Bowenoid papulosis, Bowen disease, Erythroplasia of Queyrat, and squamous cell carcinoma in situ of the penis. Initial treatment of early-stage disease is surgical and has a good prognosis.