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Updated: Jan 8, 2026

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Low Anterior Resection Syndrome Evaluation and Management.

Samantha M Linhares1, Anne K Mongiu1

  • 1Division of Colon and Rectal Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut.

Clinics in Colon and Rectal Surgery
|December 22, 2025
PubMed
Summary

Low anterior resection syndrome (LARS) causes significant quality of life issues after rectal cancer surgery. This review evaluates LARS assessment tools and treatments, highlighting the need for standardized care and further research.

Keywords:
low anterior resectionlow anterior resection syndromerectal cancer

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Area of Science:

  • Colorectal Surgery
  • Gastroenterology
  • Oncology

Background:

  • Low anterior resection syndrome (LARS) is a common, debilitating condition following rectal cancer surgery.
  • Symptoms include bowel incontinence, urgency, and clustering, significantly impacting patient quality of life.
  • Up to 80% of patients experience LARS, necessitating effective management strategies.

Purpose of the Study:

  • To review and evaluate current assessment tools for LARS.
  • To explore established and emerging treatment options for LARS.
  • To assess the evidence supporting different LARS management strategies.

Main Methods:

  • Comprehensive literature review of LARS evaluation and treatment.
  • Inclusion of ongoing clinical trials up to 2024.
  • Analysis of diagnostic tools and therapeutic interventions.

Main Results:

  • The definition of LARS has been recently revised, but validated diagnostic tools lag behind.
  • A tiered treatment approach is outlined: optimizing bowel habits, dietary changes, and medications (first-line); pelvic floor rehabilitation or transanal irrigation (second-line); neuromodulation or stoma creation (third-line).
  • Evidence supporting current strategies requires further refinement.

Conclusions:

  • LARS is a complex disorder with challenges in consistent assessment and effective treatment.
  • Opportunities exist for standardizing preoperative education, evaluation, and treatment escalation.
  • Further research into psychosocial support and a clear treatment algorithm is crucial.