Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

375
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
375
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

242
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
242
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

429
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
429
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

218
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
218
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

373
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
373

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era.

Annals of thoracic surgery short reports·2026
Same author

Cardiometabolic health and the timing of habitual exercise in the All of Us Research Program.

medRxiv : the preprint server for health sciences·2026
Same author

Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection.

Biomechanics and modeling in mechanobiology·2025
Same author

Thoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link.

Aorta (Stamford, Conn.)·2025
Same author

Investigating the role of structural wall stress on aortic growth prognosis in acute uncomplicated type B aortic dissection.

Research square·2025
Same author

Thoracic aortic aneurysm.

Nature reviews. Disease primers·2025

Related Experiment Video

Updated: Jan 8, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

811

Novel Aortic Root Measurement Technique Using the Laplace Diameter for Identifying Patients at Risk for Type A

Asanish Kalyanasundaram1, Lisa C Harling1,2, Mohammad A Zafar1

  • 1Aortic Institute, Yale University, New Haven, Connecticut.

Annals of Thoracic Surgery Short Reports
|December 22, 2025
PubMed
Summary
This summary is machine-generated.

The novel Laplace diameter accurately measures aortic root dimensions, potentially preventing aortic dissection. This method offers a 16.1% increase in mean root diameter measurement, aiding early detection.

More Related Videos

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.0K
Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

811
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

40.0K
Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.7K

Area of Science:

  • Cardiovascular Imaging
  • Biomechanical Engineering
  • Medical Diagnostics

Background:

  • The Laplace law, used for aortic wall stress, is inaccurate for the non-circular aortic root.
  • A new mathematical technique, the Laplace diameter, was developed for the cloverleaf-shaped aortic root.
  • Aortic dissection risk is linked to aortic wall stress in dilated aortas.

Purpose of the Study:

  • To evaluate the predictive capability of the Laplace diameter against standard measurements for aortic dissection risk.
  • To validate a novel method for assessing aortic root dimensions and dissection risk.

Main Methods:

  • Computed tomographic scans from 33 patients with predissection scans were analyzed.
  • The Laplace diameter was compared with the standard sinus-to-commissure measurement.
  • Scans were obtained in close temporal proximity to acute aortic events.

Main Results:

  • The Laplace diameter showed a 16.1% increase in mean aortic root diameter.
  • Applying the Laplace diameter could have enabled detection and prevention of aortic dissection in 21.4% of cases.
  • The novel method was clinically validated for aortic root diameter determination.

Conclusions:

  • The Laplace diameter is a clinically validated method for accurately measuring the aortic root.
  • This technique improves the detection of aortic dissection risk.
  • The Laplace diameter offers a more precise assessment of aortic root geometry compared to traditional methods.