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  1. Home
  3. Standardized Ginkgo Biloba Extract (egb 761) For Knee Osteoarthritis: A Narrative Review.
  1. Home
  3. Standardized Ginkgo Biloba Extract (egb 761) For Knee Osteoarthritis: A Narrative Review.

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Standardized Ginkgo Biloba Extract (EGb 761) for Knee Osteoarthritis: A Narrative Review.

Yunqing Wang1,2, Ziyu Liu1,2, Yong Liu1

  • 1Department of Traumatic Orthopedics, Affiliated Hospital of Shandong Second Medical University, Weifang, 261031, People's Republic of China.

Drug Design, Development and Therapy
|December 22, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Ginkgo biloba extract (EGb 761) shows potential for knee osteoarthritis (KOA) by reducing inflammation and improving function. However, more high-quality trials are needed to confirm its therapeutic benefits for KOA patients.

Keywords:
EGb 761KOAefficacy and therapeutic effectginkgo biloba extractknee osteoarthritis

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Area of Science:

  • Orthopedics and Sports Medicine
  • Pharmacology and Pharmaceutical Sciences
  • Natural Product Research

Background:

  • Knee osteoarthritis (KOA) is a debilitating degenerative joint disease with limited treatment options.
  • Ginkgo biloba extract (EGb 761) possesses anti-inflammatory, antioxidant, and chondroprotective properties.

Purpose of the Study:

  • To review current evidence on the therapeutic potential of EGb 761 for knee osteoarthritis.
  • To evaluate EGb 761 as an adjunctive therapy for KOA, considering its multi-target pharmacological actions.

Main Methods:

  • A narrative review of experimental and clinical studies on EGb 761 in KOA.
  • Literature search conducted in PubMed, Scopus, and Web of Science up to 2025.

Main Results:

  • Preclinical and clinical data suggest EGb 761 may decrease inflammation, oxidative stress, and chondrocyte apoptosis in KOA.
  • Modest improvements in pain relief and joint function were observed, with a favorable safety profile.

Conclusions:

  • Current evidence suggests EGb 761 may offer some benefits for KOA, but findings are limited by study quality and size.
  • Further high-quality randomized controlled trials are necessary to definitively establish the efficacy of EGb 761 for knee osteoarthritis.