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Related Experiment Video

Updated: Jan 8, 2026

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

Molecular tools for decoding multicellular systems: from mechanisms to medicine.

Jie P Li^1,2, Weiming Guo^2,3, Peng Zou^2,3

¹State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

National Science Review

|December 22, 2025

Summary

New molecular tools offer unprecedented insights into cell-cell communication (CCC), crucial for health and disease. These advancements hold promise for precision medicine, targeting cell interactions for treating complex diseases.

Keywords:

cell-cell communication molecular tools precision medicine proximity labeling spatial omics

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Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

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Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

Area of Science:

Multicellular Systems Biology
Chemical Biology
Medical Science

Background:

Cell-cell communication (CCC) is vital for biological processes like growth, differentiation, immune surveillance, and tissue homeostasis.
Dysregulation of CCC is implicated in diseases including cancer, autoimmunity, and neurodegeneration.
Decoding complex multicellular interactions is a growing area of scientific interest.

Purpose of the Study:

To review recent interdisciplinary breakthroughs in understanding cell-cell communication.
To highlight advanced molecular tools enabling deeper insights into CCC.
To discuss the translational potential of these tools in medicine.

Main Methods:

Review of advancements in molecular tools for studying CCC.
Focus on techniques like super-resolution imaging, proximity labeling, bioorthogonal chemistry, synthetic receptors, and single-cell spatial omics.
Discussion of interdisciplinary approaches from the 380th Shuangqing Forum.

Main Results:

Molecular tools provide unprecedented spatial, molecular, and functional insights into CCC.
These tools enable a deeper understanding of the complexities of multicellular systems.
Significant translational potential for applications in immuno-oncology, regenerative medicine, and autoimmune diseases.

Conclusions:

Advanced molecular tools are revolutionizing the study of cell-cell communication.
These technologies offer significant promise for developing targeted therapies for complex diseases.
Advocacy for a future precision medicine framework focused on modulating cell-cell interactions.