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Related Concept Videos

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Inflammatory Bowel Disease V: Surgical Management

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Consensus Statements for Clinical Practice in Advanced/Metastatic Colorectal Cancers in India Using a Modified Delphi

Anant Ramaswamy1, Sujay Srinivas2, Viraj Lavingia3

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Summary
This summary is machine-generated.

This study provides evidence-based guidelines for managing metastatic colorectal cancer (mCRC) in India. It addresses unique challenges and resource constraints faced by oncologists treating advanced colorectal cancer.

Keywords:
India specificmetastatic colorectal cancermodified Delphi consensus

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Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a prevalent malignancy globally and the fourth most common cancer in Indian men (GLOBOCAN 2020).
  • Approximately 30% of patients present with advanced or metastatic colorectal cancer (mCRC).
  • This publication addresses the specific challenges in managing mCRC within the Indian healthcare landscape.

Purpose of the Study:

  • To summarize the latest evidence for mCRC management tailored to the Indian context.
  • To develop consensus statements for medical oncologists treating mCRC, considering unique national challenges.
  • To focus on the recognition, management, and systemic therapeutic approaches for mCRC.

Main Methods:

  • A panel of 38 medical oncologists convened in February 2023.
  • Evidence review focused on mCRC recognition, management, and systemic therapies.
  • Consensus statements were formulated using a literature review and evaluated via the modified Delphi method.

Main Results:

  • Fifty-one consensus statements were developed for managing mCRC, including oligometastatic and unresectable cases.
  • The statements encompass various systemic therapeutic options.
  • Consideration was given to resource-constrained scenarios, including economic factors and drug availability in India.

Conclusions:

  • The consensus statements provide practical, evidence-based guidelines for mCRC treatment in India.
  • Recommendations are stratified for resource-constrained settings.
  • These guidelines aim to improve the management of advanced colorectal cancer in India.