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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
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Prevalence of Cancer-Related Fatigue: A Prospective Observational Study
Pradeep K Reddy1, Billakanti Rajkumar1, S P Shrivastava2
1Department of General Medicine, SVS Medical College, Hyderabad, Telangana, India.
South Asian Journal of Cancer
|December 22, 2025
Summary
Cancer-related fatigue (CRF) significantly impacts Indian patients, with most experiencing moderate to severe symptoms. Early assessment and management of CRF are crucial for improving cancer patients
Area of Science:
- Oncology
- Quality of Life Research
- Patient Experience
Background:
- Cancer-related fatigue (CRF) is a prevalent issue affecting cancer patients' quality of life and daily activities.
- Limited data exists on CRF prevalence and impact within the Indian population.
- Understanding CRF in India is essential for targeted patient care and management strategies.
Purpose of the Study:
- To determine the prevalence of cancer-related fatigue (CRF) in Indian cancer patients.
- To assess the impact of CRF on the quality of life for this patient group.
- To provide data for improved CRF management protocols in India.
Main Methods:
- A prospective observational study was conducted over 6 months with 100 adult cancer patients in Telangana, India.
- Patients with brain metastases were excluded to ensure reliable data collection.
- Fatigue levels were assessed using the EORTC QLQ-C30 and NCCN fatigue intensity scales.
Main Results:
- The study included 100 Indian patients (49% male, 51% female) with a mean age of 43.78 years.
- Breast and gastric cancers were the most common diagnoses (22% each).
- Using the EORTC QLQ-C30 scale, 76% of patients reported moderate to severe fatigue; the NCCN scale indicated 44% had severe fatigue.
Conclusions:
- A significant proportion of Indian cancer patients experience moderate to severe cancer-related fatigue.
- The findings highlight the need for routine CRF assessment and management in clinical practice.
- Implementing effective CRF management strategies can improve overall patient care and quality of life.
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