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Time-Weighted Cumulative High-Sensitivity C-Reactive Protein and Risk of Cardiac Conduction Block: Findings from a

Mo Zhang1,2, Dou Shi1, Yixiu Chen2,3

  • 1Graduate School, Hebei North University, Zhangjiakou City, Hebei Province, 075000, People's Republic of China.

Journal of Inflammation Research
|December 22, 2025
PubMed

Insights

Elevated cumulative exposure to high-sensitivity C-reactive protein (cumhsCRP) significantly increases the risk of cardiac conduction block (CCB). This finding highlights inflammation

Area of Science:

  • Cardiology
  • Inflammation Research
  • Preventive Medicine

Background:

  • Chronic low-grade inflammation is a known risk factor for cardiovascular events.
  • High-sensitivity C-reactive protein (hsCRP) is a key biomarker of inflammation.

Purpose of the Study:

  • To investigate the association between cumulative hsCRP exposure and new-onset cardiac conduction block (CCB).
  • To evaluate the dose-response relationship between time-weighted cumulative hsCRP and CCB risk.

Main Methods:

  • Prospective community-based cohort study of 48,703 participants.
  • Analysis of time-weighted cumulative hsCRP over an average of 6.36 years.
  • Cox proportional hazards models and restricted cubic spline analysis to assess CCB risk.

Main Results:

  • A total of 803 new-onset CCB cases were identified over 9.24 years.
  • Elevated cumulative hsCRP (≥ 2 mg/L) was independently associated with a 24% increased risk of CCB (HR: 1.24, 95% CI: 1.07-1.44).
  • A linear association was observed between cumulative hsCRP and CCB risk.

Conclusions:

  • Cumulative exposure to hsCRP is an independent predictor of CCB development.
  • This association is particularly noted for left bundle branch block and left anterior fascicular block.
  • Findings offer insights for CCB prevention strategies targeting inflammation.
Abstract

Keywords:
cardiac conduction blockcumulative exposurehigh-sensitivity C-reactive proteininflammation

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