Related Experiment Video

Updated: Jan 8, 2026

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

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Successful ventilator weaning after aerosolized liposomal amphotericin B in persistent Candida glabrata colonization:

Massimo Caracciolo1, Simona Pellicano1, Sarah Antonella Caracciolo2

  • 1UOSD Post-Operative Intensive Care Unit, Great Metropolitan Hospital Bianchi Melacrino Morelli, Reggio Calabria, Italy.

Frontiers in Medicine
|December 22, 2025
PubMed
Abstract

Insights

Aerosolized liposomal amphotericin B effectively treated persistent Candida glabrata airway colonization in a critically ill patient. This approach aided successful mechanical ventilation weaning, demonstrating a promising local therapy for challenging fungal infections.

Area of Science:

  • Critical Care Medicine
  • Mycology
  • Pulmonology

Background:

  • Invasive candidiasis and airway colonization by non-albicans Candida species, particularly Nakaseomyces glabrata (formerly Candida glabrata), pose significant challenges in critically ill patients requiring mechanical ventilation.
  • N. glabrata presents unique resistance and immune evasion mechanisms, complicating treatment strategies.
  • Aerosolized liposomal amphotericin B (Ambisome®) is explored as a targeted local therapy with a favorable safety profile.
Keywords:
Aerogen vibrating mesh deviceCandida glabrata Nakaseomyces glabrataICUaerosolized amphotericin Bfungal colonizationimmune evasionliposomal formulationventilator weaning

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