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Multiple Chemical Sensitivity: an Italian prevalence multicentric survey
Giovanni Genovese1, Caterina Elisabetta Rizzo1, Antonio Mistretta2,3
1Department of Biomedical Sciences and Morphological and Functional Images (BIOMORF), University of Messina, Messina, Italy.
Frontiers in Public Health
|December 22, 2025
Summary
Multiple Chemical Sensitivity (MCS) affects 5.7% of the population, with many experiencing chemical intolerance. This study highlights the need for better diagnostic tools and management strategies for this environmental health condition.
Area of Science:
- Environmental Health
- Clinical Toxicology
- Epidemiology
Background:
- Multiple Chemical Sensitivity (MCS) is a recognized multisystem disorder.
- It is triggered by chemical exposures below toxic levels.
- MCS significantly impacts patient health and quality of life.
Purpose of the Study:
- To determine the prevalence of MCS in the general population.
- To identify common symptoms and risk factors.
- To evaluate the utility of the QEESI questionnaire for MCS assessment.
Main Methods:
- A multicenter retrospective study involving 494 adults.
- Participants completed the Quick Environmental Exposure and Sensitivity Inventory (QEESI).
- Data analysis included clinical, environmental, and socio-demographic factors.
Main Results:
- 5.7% of the population showed MCS symptoms; 10.73% were highly suggestive.
- Chemical intolerance was prevalent (86.4%), linked to various exposures.
- Symptom severity correlated with chemical intolerance and sensory sensitivities.
Conclusions:
- MCS symptoms are present in a notable portion of the general population.
- A significant percentage may be vulnerable to chemical exposures.
- Standardized diagnostics and multidisciplinary care are recommended.
