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Understanding social context in HIV and drug use via community-informed computational modeling: SILOS study protocol.
Joshua Z Stadlan1,2, Patrick F Janulis1, Tom Wolff1
1Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Frontiers in Public Health
|December 22, 2025
Summary
This study investigated how social networks and environment influence HIV risk in marginalized populations. The project was paused, but aims to reveal structural drivers of health inequity.
Area of Science:
- Public Health
- Epidemiology
- Social Network Analysis
Background:
- Racial, ethnic, and sexual and gender minority populations experience disproportionate HIV impacts.
- Understanding complex factors driving health disparities in these groups is critical.
Purpose of the Study:
- To investigate social and contextual systems influencing HIV risk among marginalized populations.
- To examine how access to people and places confers HIV risk.
Main Methods:
- An observational study planned across five US cities.
- In-depth remote network surveys administered to 2,700 racially diverse young men who have sex with men and transgender women.
- Development of simulation models using city-specific synthetic populations to analyze HIV risk factors.
Main Results:
- The study was awarded in August 2024 but paused in March 2025 due to NIH termination prior to participant recruitment.
- The future of the research is uncertain pending reinstatement efforts.
Conclusions:
- The project, leveraging network modeling and community partnerships, is poised to advance understanding of structural drivers of health inequity.
- Despite setbacks, the research aims to transform the scientific understanding of health disparities.
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