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Acral Melanosis with Macromelanosomes (AMM): The First AI-Defined Pathological Entity and Proposal of Provisional
Igor Shendrik1, Svetlana Bobkova2
1Dermatopathology Section, Pathology Laboratory Associates, Tulsa, USA.
Abstract:
Artificial intelligence (AI) has started to transform diagnostic workflows in pathology, yet no formal pathological entity has been named, defined, and documented in the medical literature by an AI system. We report a benign acral pigmentary process characterized by conspicuous keratinocyte macromelanosomes with otherwise normal melanocyte density and architecture. We propose the term "acral melanosis with macromelanosomes (AMM)," a name and construct first generated with the assistance of a large language model (ChatGPT), and we present clinical, histologic, and special‑stain findings along with provisional diagnostic criteria.

