Related Experiment Video
Updated: Jan 8, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Prevalence of Vitamin D Deficiency in Patients Admitted With Recent Fragility Hip Fracture: A Single-Center
Chagigia Mousa1, Christos Zafeiris2, George Lyritis3,4
1Orthopedic Surgery, Athens Medical Center, Athens, GRC.
Abstract:
Hip fractures are the most common low‑energy injury affecting older adults and place a large burden on healthcare systems. Vitamin D sufficiency is fundamental to healthy bone turnover, maintenance of muscular strength, and immune system homeostasis. We aimed to evaluate the prevalence of vitamin D deficiency among patients admitted with recent fragility hip fractures at a single orthopedic clinic over one year. This retrospective study included patients aged >50 years admitted to the General Hospital of Athens "KAT" with fragility hip fractures during 12 months. Preoperative assessment included quantification of serum 25-hydroxyvitamin D (25(OH)D). Patients with bilateral hip fractures, chronic diseases affecting bone, polytrauma, and high‑energy trauma were excluded. Vitamin D status was categorized as deficiency <10 ng/mL, insufficiency 10-20 ng/mL, sufficiency >20 ng/mL. Of 186 patients presenting with hip fractures, 129 met the inclusion criteria (mean age 81.7 years; 72.9% female). Intertrochanteric fractures comprised 84 (65.1%). Deficiency of vitamin D was found in 72 (55.8%), insufficiency in 40 (31%), and sufficiency in 17 (13.2%). No statistically significant difference was observed between the sexes. Our data indicate a markedly high prevalence of vitamin D deficiency in older patients presenting with hip fractures. Consequently, we recommend introducing screening and prevention strategies.
Related Concept Videos
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Skeleton and Calcium Homeostasis
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...

