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Factors Affecting Tablet Disintegration by Immersion in Food Thickener Solution

Shinya Sugiura1, Megumi Nakamura2, Miku Hashimoto2

  • 1Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, JPN.

Cureus
|December 22, 2025
PubMed
Summary

Food thickeners like xanthan gum significantly delay tablet disintegration, impacting medication effectiveness. Starch-based thickeners, however, do not affect disintegration times.

Keywords:
disintegrationfood thickenerimmersionimpaired swallowingtablet

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