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Immune-Mediated Thrombocytopenia Induced by Niraparib: A Clinically Relevant Case
Fernando Roxo1, Delfim Duarte2,3,4, Miguel H Abreu1
1Department of Medical Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, PRT.
Cureus
|December 22, 2025
Summary
Niraparib can cause rare immune-mediated thrombocytopenia in ovarian cancer patients. Prompt steroid treatment and drug withdrawal are crucial for managing this severe side effect.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Immune-mediated thrombocytopenia (IMT) is a rare but serious adverse event associated with niraparib.
- The true incidence and clinical presentation of niraparib-induced IMT remain poorly understood due to scarce pharmacovigilance data.
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