Endoscopic Controlled Radial Expansion Balloon Dilatation in Infantile Achalasia: A Case Series of Four Infants
View abstract on PubMed
Summary
This summary is machine-generated.Infantile achalasia, a rare esophageal disorder, presents diagnostic challenges. Controlled radial expansion (CRE) balloon dilatation offers a safe and effective treatment, with 75% of infants showing significant improvement.
Area Of Science
- Pediatric Gastroenterology
- Esophageal Motility Disorders
- Pediatric Endoscopy
Background
- Achalasia cardia is an uncommon esophageal motility disorder often misdiagnosed as GERD.
- Infantile achalasia presents unique diagnostic and therapeutic challenges due to symptom overlap and difficulties with standard diagnostic tools.
- Allgrove (Triple-A) syndrome, though rare, must be considered in the differential diagnosis.
Purpose Of The Study
- To describe the diagnostic and therapeutic approach to infantile achalasia.
- To evaluate the efficacy and safety of controlled radial expansion (CRE) balloon dilatation in infants with achalasia cardia.
- To highlight the role of timed barium esophagogram (TBE) in diagnosis.
Main Methods
- Case series of four infants diagnosed with achalasia cardia based on TBE findings.
- Exclusion of congenital esophageal stenosis through endoscopic and radiologic evaluation.
- Serial CRE balloon dilatation performed under endoscopic vision for lower esophageal sphincter (LES) obstruction.
Main Results
- Three out of four (75%) infants experienced marked clinical improvement after CRE balloon dilatation.
- Infants remained symptom-free at a median follow-up of 4.5 months.
- The procedure was uneventful, demonstrating safety and feasibility.
Conclusions
- Infantile achalasia is diagnostically challenging but TBE is a key diagnostic tool.
- Endoscopic CRE balloon dilatation is a safe, minimally invasive, and effective treatment for infantile achalasia.
- Sustained symptom remission and nutritional recovery support the clinical value of CRE balloon dilatation.

