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Updated: Jan 8, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma
Wan Li1, Keming Zhou2, Mengyan Li1
1Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Objective:
The present investigation was aimed to examine ubiquitin-conjugating enzyme E2S (UBE2S), hypoxia-inducible factor (HIF)-1α, and factor forkhead box M1 (FOXM1) levels in esophageal squamous cell carcinoma (ESCC) and esophageal low-grade intraepithelial neoplasia (LIN), high-grade intraepithelial neoplasia (HIN). Additionally, the investigation explored the correlation between these levels and clinicopathological features in addition to prognosis.
Methods:
To investigate the expression patterns of UBE2S, HIF-1α, and FOXM1, immunohistochemical staining was performed on tissue samples, including LIN, HIN, ESCC, and healthy controls. Subsequently, the chi-square test was applied to analyze the correlations between the expression levels of the three proteins and the clinicopathological features of ESCC. The impact of UBE2S, HIF-1α, and FOXM1 on ESCC prognosis was evaluated using survival analysis. Spearman correlation analysis was employed to analyze the correlation of three proteins in ESCC, HIN, and LIN, respectively.
Results:
UBE2S overexpression was related to ethnicity (p < 0.001) and the place of the tumor (p = 0.021). Overexpression of HIF-1α (p = 0.017) and FOXM1 (p = 0.015) was connected to metastasis of the lymph node. Individuals with elevated levels of UBE2S, HIF-1α, and FOXM1 had reduced overall survival (OS) and progression-free survival (PFS).
Conclusion:
The expression levels of UBE2S, HIF-1α, and FOXM1 are closely associated with the incidence and progression of ESCC. UBE2S, HIF-1α, and FOXM1 have potential as prognostic indicators for ESCC.
