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RNY1 partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation to regulate

Cherie E Saffold1,2,3,4, Antiana C Richardson1,2,3,4, Heather H Pua1,2,3,4

  • 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Biorxiv : the Preprint Server for Biology
|December 22, 2025
PubMed
Summary

Extracellular YRNAs (exYRNAs) in airway fluid, particularly RNY1, signal lung inflammation by packaging into extracellular vesicles and ribonucleoproteins, influencing macrophage responses and neutrophil infiltration.

Keywords:
M2 macrophageRNY1YRNAbronchoalveolar lavage fluidextracellular RNAextracellular vesiclelung inflammation

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