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Updated: Jan 8, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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JNJ-55511118 Stabilizes a Desensitized-like Conformation of γ8-Containing AMPA Receptors through Long-Range

Paola Carrillo Flores1, Vladimir Berka1, Vasanthi Jayaraman1

  • 1Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX, USA.

Biorxiv : the Preprint Server for Biology
|December 22, 2025
PubMed
Summary

JNJ-118, a selective inhibitor, stabilizes desensitized AMPA receptors (AMPARs) by modulating their structure. This drug acts as a long-range allosteric modulator, inhibiting receptor function without dissociating auxiliary proteins.

Keywords:
AMPA receptorTARP γ8allosteric modulationdesensitizationelectrophysiologysmFRET

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