4,7-Functionalization of Tetradentate Phenanthroline Ligands via Nucleophilic Substitution of Fluorine
Roman V Zonov1, Nane A Avagyan1, Pavel S Lemport1
1Department of Chemistry, Lomonosov Moscow State University, Leninskie gory 1 bld. 3, Moscow 119991, Russia.
Abstract:
An effective pathway for the functionalization of 1,10-phenanthroline-2,9-dicarboxamides (DAPhen) to positions 4 and 7 of the heterocyclic backbone by nucleophilic aromatic substitution was developed. The developed approach makes it possible to introduce various functional groups of almost any nature into positions 4 and 7 of the phenanthroline nucleus. The introduction of reactive functional groups, such as the azide group, has allowed for further functionalization. Thus, a set of novel symmetrically or unsymmetrically 4,7-disubstituted DAPhen ligands was prepared.
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Nucleophilic Aromatic Substitution: Elimination–Addition
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
Diazonium Group Substitution: –OH and –H
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions


